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Principal Scientist - Medicinal Chemistry


The Woodlands, TX, US / San Francisco, CA, US
  • Job Type: Full-Time
  • Function: Life Sciences R&D/Engineering
  • Industry: Biotechnology
  • Post Date: 04/15/2024
  • Website:
  • Company Address: 1700 Owens Street, Suite 205, San Francisco, CA, 94158
  • Salary Range: $50,000 - $150,000

About Nurix

Nurix Therapeutics discovers drugs that harness the body's natural process to control protein levels.

Job Description

About the Position

We are seeking a talented and highly motivated individual with a strong background in synthetic organic chemistry to join our medicinal chemistry group in the pursuit of novel small molecules to treat patients with unmet medical needs. The successful candidate may lead a project team and/or a group of medicinal chemists and will engage in rational structure-based drug discovery enabled by our computational and structural biology group. Specifically, this individual will design and synthesize novel chemical entities optimized for potency, selectivity, pharmacokinetics and in vivo efficacy. As a member of a dynamic multi-disciplinary team, this person will collaborate with a broad group of scientists within Nurix and with external collaborators. Additionally, they will contribute effectively to patent, report and scientific publication writing. Furthermore, they will initiate and/or lead process improvements within the chemistry lab or cross-functionally.


  • Ph.D. in synthetic organic chemistry with 10+ years pharmaceutical medicinal chemistry industrial experience
  • Successful application of structure-based drug design leading to advanced leads/ development candidates. Strong working knowledge of protein-ligand interactions, conformational and structural analysis, experienced in partnering closely with computational chemists through appropriate use of computational tools, models and visualization applications.
  • High level of creativity and productivity with strong synthetic problem-solving skills.
  • Excellent scientific expertise in organic synthesis, conversant with the current literature.
  • Ability to champion the chemistry efforts into new directions to achieve project milestones.
  • Solid track record of innovation and impact on programs, with direct contributions to company pipelines (including both successful project advances and smart terminations).
  • Proven leadership capability in cross-functional team setting, either as project team leader or co-lead.
  • Proven track record of supervising PhD level scientists to high levels of productivity, whilst improving the skills and knowledge of direct reports through mentorship and focused development activities.
  • Ability to manage priorities and advance multiple projects simultaneously.
  • Strong evidence of conceptual thinking and active follow through, recognized by establishing new projects or new directions within projects, new strategies and/or enabling technologies for drug discovery. Vigorous scientific curiosity as evidenced by contributions to diverse medicinal chemistry strategies.
  • Ability to make inventive contributions towards new chemical target structures or templates for programs and employ sound judgment in the evaluation and strategic decision making around early screening or literature hits.
  • Excellent knowledge of medicinal chemistry principles with a solid understanding of the basic biology and pharmacology of programs, the ADME issues, and series SAR. Able to effectively integrate this knowledge and apply the key principles of medicinal chemistry, literature precedent, and drug design to direct medicinal chemistry programs to phase transitions or series go/no go decisions.
  • Strong skills in gathering, documenting, and analyzing information from competitive sources such as patents and meetings and using this information to guide program strategy.
  • Excellent communication skills and the ability to present rationale, key data, issues and accomplishments of the chemistry efforts to the company.

Fit with Nurix Culture and Values

  • Strong team orientation; highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view

We are an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.

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