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Principal Scientist, DMPK

Revolution Medicines

Redwood City, CA, US
  • Job Type: Full-Time
  • Function: Clinical Research
  • Industry: Biotechnology
  • Post Date: 02/12/2024
  • Website:
  • Company Address: 700 Saginaw Dr, Redwood City, California 94063, US

About Revolution Medicines

REVOLUTION Medicines discovers and develops new drugs that harness the therapeutic potential of frontier oncology targets on behalf of cancer patients.

Job Description

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding scientists in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

The DMPK Principal Scientist would serve as an in-house expert and technical leader and be a critical part of the Nonclinical Development and Clinical Pharmacology (NDCP) Organization.

Specifically, you will:

  • Be a key leader within DMPK function, plan and implement ADME/PK strategies to drive key project decisions for advancing small molecule programs.

  • Represent DMPK on multi-disciplinary teams, design and manage the conduct of experiments at CROs in a timely manner to understand the drug disposition profile, PK-PD relationship, TK-safety, translation of dose regimens from preclinical to clinical, and contribute to IND filing.

  • Play a critical role in studying drug candidate tissue distribution (e.g., QWBA), elimination, and DDI potential, design and manage outsourced nonclinical development ADME studies in support of clinical pharmacology plans.

  • Author and review DMPK sections of regulatory submissions and respond to questions from regulatory agencies.

  • Build and maintain strong collaborative partnerships with Biology/Pharmacology, Clinical Pharmacology, Medicinal Chemistry, Pharmaceutical Development, Toxicology, and Translational Research.

Required Experience, Skills, and Education:

  • A highly motivated individual with a Ph.D. in Pharmaceutic Sciences or a related scientific discipline, with at least 5 years of industry experience.

  • Deep understanding of ADME principles, extensive knowledge, and hands-on experience in developing in vitro/in vivo assays and tools to characterize preclinical ADME/PK and DDI profiles of small molecules.

  • A solid understanding of regulatory guidelines on DMPK/DDI studies to support early oncology drug development is highly desirable.

  • Strong track record in leading small molecule drug discovery programs, demonstrated by successful advancement of discovery programs to IND filing.

  • Solid knowledge and experience in the application of PK and basic compartmental modeling software.

  • Excellent verbal and written communication, problem-solving, and critical thinking skills.

  • Thrives in a collaborative team setting and is driven by a desire to be innovative in a highly energetic and fast-paced environment.

Revolution Medicines currently requires that all personnel and visitors to its offices be fully vaccinated against COVID-19. This role will require that the employee meet with company employees and work from the company’s offices. Given that these essential functions of the role must be performed on-site, this position requires full COVID-19 vaccination, subject to applicable law.

The expected salary range for this role is $195,000 to $260,000. An individual’s position within the range may be influenced by multiple factors, including skills and experience in role, overall performance, individual impact and contributions, tenure, and market dynamics. Base salary is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition and veteran status.

Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact

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