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DEL Screening Intern - Contract


San Francisco, CA, US
  • Job Type: Intern
  • Function: Intern
  • Industry: Biotechnology
  • Post Date: 07/08/2024
  • Website:
  • Company Address: 1700 Owens Street, Suite 205, San Francisco, CA, 94158

About Nurix

Nurix Therapeutics discovers drugs that harness the body's natural process to control protein levels.

Job Description


Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.


We are seeking a skilled and motivated individual with experience in protein biochemistry, molecular biology, or ligand screening techniques to join our DEL Discovery team into a six-month contract (with an opportunity to renew) at Nurix headquarters in San Francisco, CA. The successful candidate will support DNA-encoded library (DEL) screening efforts for discovery of small molecule binders to relevant protein targets. These duties will include planning, execution, and analysis of DEL screens along with assisting in post-DEL screen sequencing. This individual will work closely with scientists from cross-functional disciplines and present findings to project teams. The ideal candidate will be self-driven, highly organized, highly detail-oriented, and enjoy working in a dynamic team environment.

Required Qualifications

  • BS or MS in Molecular Biology, Biochemistry, or related field with 0-2 years industry experience.
  • Strong interest in learning the DNA-encoded library screening process.
  • Practical knowledge of biochemistry and protein chemistry assays.
  • General understanding of protein production/expression systems.
  • Strong organizational skills, attention to detail, and communication.
  • Experience in presenting data to scientists from both similar and cross-functional disciplines.

Bonus Qualifications

  • Knowledge of PCR amplification assays.
  • Knowledge of DNA sequencing techniques (including but not limited to Sanger and next-generation sequencing).
  • Experience with assay development.
  • Knowledge of chimeric targeting molecules (CTMs) and the ubiquitin proteosome system (UPS).

Fit with Nurix Culture and Values

  • Team-oriented and collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view


Pay range in San Francisco, CA
Exact compensation may vary based on skills, experience, and location.

Hourly Rate
$25/hr. - $35/hr.


Application Process

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US. Applications can be submitted on our website:

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