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Senior Research Associate, Biology

Remix Therapeutics

Watertown, MA, US
  • Job Type: Full-Time
  • Function: Research Sci/Assoc/Mgr
  • Industry: Biotechnology
  • Post Date: 07/01/2024
  • Website: www.remixtx.com
  • Company Address: 100 Forge Rd, Watertown, MA 02472, US

About Remix Therapeutics

Remix launched in 2020 with a vision to transform patient's lives through modulation of RNA processing.

Job Description

Remix launched with a vision to transform patient’s lives through modulation of RNA processing. Our breakthrough science provides a path to identify small molecules that impact the expression of disease driving mRNAs and proteins. We take on the challenge of addressing drug targets in diseases of high unmet medical need to bring new therapeutic options to patients. Remix has a commitment to demonstrate the highest levels of scientific integrity with urgency because those patients are counting on us to deliver. With an in-house technology platform built from scratch, we have rapidly generated multiple drug discovery programs that are advancing towards the clinic.

Position Summary:

We seek a highly motivated, experienced molecular/cellular biologist to join our team located in Watertown, MA. The successful candidate will be an instrumental contributor within the Biology Department, helping to conduct mechanistic studies using small molecules and genetic tools across a variety of assays. 

The individual will have a strong background in molecular/cellular biology or another applicable field and will design and execute in-cell experiments across multiple stages of drug development (e.g., early stage target validation through to lead optimization). They will have a track-record of success within a hypothesis-driven, team-oriented, and interdisciplinary laboratory setting. They will be expected to contribute to data generation, analysis, and visualization, as well as communicating with a cross-functional team of scientists in a thriving biotech environment. 

Principle Duties and Responsibilities:

  • Design and develop a wide range of in cell assays to profile small molecules and/or genetic tools to better understand compound mechanism of action 
  • Execute assessments or RNA and protein modulation including qRT-PCR, immunoblots, plate-based assays, and preparing samples for RNAseq 
  • Evaluate and implement novel cell-based assays  
  • Document, interpret, and regularly report research findings in an open and timely manner in small group and company-wide meetings 
  • Build and maintain productive relationships with colleagues across all disciplines, including those in biology, pharmacology, biomolecular sciences, bioinformatics, and chemistry

Qualifications:

  • BS, M.Sc. or equivalent in cellular biology, molecular biology, or a related discipline with 3-5+ years of experience working in a pharmaceutical/biotechnology laboratory setting 
  • Proficiency in culturing cells and performing various in-cell assays and manipulations including qPCR, immunoblots, ELISA/HTRF, viability, transfections, compound treatments 
  • Experienced in independently implementing new assays, conducting thorough data analysis, and excellent record-keeping skills 
  • Familiarity with cell line engineering preferred (CRISPR, lentiviral, etc)  
  • Operate effectively and collaboratively in a multi-disciplinary, team-focused environment

Remix values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation, or any other legally protected status. Remix will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Note to Third Party Staffing Agencies: Please do not forward any agency resumes. Remix Therapeutics is not responsible for any fees related to resumes that are unsolicited.

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