Job Description

Topo Therapeutics is an early-stage startup biotech company in One Kendall Square in Cambridge. Topo’s mission is to develop small molecule therapeutics for the treatment of neurological and rare diseases by leveraging novel insights into protein structure and small molecule-protein interactions.  Backed by top-tier life science investors, Topo brings together scientific founders who are world leaders in the fields of protein structure, neurobiology, and rare disease and a highly experienced team with industry-leading expertise in membrane protein pharmacology.

Position Summary

We are seeking a motivated and organized Senior Scientist with patch clamp electrophysiology and cell-based assay experience to join the Topo scientific team. This position will focus on the validation of new technologies and in vitro assays to support drug development on existing or new targets. The Senior Scientist will identify, design and execute in vitro experiments at varying scales. They will also direct external studies and projects at CROs.

Responsibilities:

• Validate existing and new therapeutic targets by designing and executing key experiments
• Develop and perform electrophysiological and cell-based assays at scale to support drug development
• Utilize patch clamp, high content imaging, plate readers, molecular biology and other research techniques
• Direct projects and studies at CROs

Skills and Requirements:

• PhD in neuroscience, biophysics or related field required
• Minimum of 2+ years in drug discovery in an industry or postdoctoral position required
• Patch clamp electrophysiology experience required
• High content microscopy or plate reader assay experience required
• Immortalized and/or primary mammalian cell culture experience required
• Experience with molecular biology techniques and/or biochemistry desired
• Strong interpersonal skills required
• Excellent attention to detail, organizational skills and computer literacy required

If you are interested in exploring work opportunities at Topo, please submit your resume noting your specific position interest to: careers@topo-tx.com

Topo is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, disability, age, sexual orientation, gender identity, national origin, veteran status, or genetic information. Topo is committed to providing access, equal opportunity, and reasonable accommodation for individuals with disabilities in employment, its services, programs, and activities.

Applicants must be authorized to work for ANY employer in the U.S. We are currently unable to sponsor or take over sponsorship of employment visas.

Employment agencies are an important component of our talent acquisition strategy, and we value the partnerships we have built with our preferred vendors. We will not accept unsolicited resumes from employment agencies for any employment opportunity.

All resumes submitted by search firms to any employee at Topo or directly to hiring managers in any form without a signed agreement between the parties will be deemed unsolicited in nature, and no fee will be paid in the event the candidate is hired as a result of the referral or through other means.