Job Description

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers.  The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding scientists in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity

We are looking for an experienced Scientist I to help the Discovery Sciences team accelerate our search for new oncology therapeutics. The successful candidate will join a high-performing team of experts in the use of biochemical and biophysical screening techniques to drive the efficient identification and rapid development of clinically impactful drugs against frontier targets in oncology. Working from the bench, they will apply their biochemical and biophysical expertise. The candidate will support Discovery Science efforts to enhance how we discover inhibitors of established and new drug target proteins, as well as contribute to our mission of providing high-quality experimental data for existing programs.

Responsibilities

• Design and execution of lead discovery screening methods and experiments to identify compound hits and advance them through hit-to-lead and lead optimization stages

• Collaborate within Discovery Science and cross-functionally with Compound Management, Structural Biology, and Biology/Chemistry teams to develop and implement biochemical and biophysical assays for hit identification and lead optimization, evaluating compound potency, selectivity, and mechanism of action, biophysical and biochemical assay development.

• Develop, execute, and troubleshoot novel biochemical and biophysical assays to support screening and preclinical development.

• Communicate scientific progress effectively to Discovery Sciences team and cross-functionally and facilitate project execution within established timelines

• Generate, manage, evaluate, and maintain critical data in an organized manner and disseminate data broadly to relevant departments

• Maintain detailed electronic lab notebook entries, draft protocols for experiments, assay data summaries, and manage reagent stocks

Required Skills, Experience and Education:

• PhD with 0-2 years experience or Master’s degree with 5+ years of experience in biochemistry, biophysics, biotechnology, or related field

• Hands-on protein biochemistry experience in: biochemical/biophysical assay development, validation, and troubleshooting (e.g., characterizing and analyzing protein-ligand or protein-protein interactions)

• Proficiency in execution and analysis of in vitro biochemical and biophysical assays suitable for the discovery, validation, or mechanistic characterization of target molecules (ITC, SPR/BLI, TR-FRET, fluorescence polarization, etc.)

• Experience with data processing and visualization tools for data analysis and figure generation (e.g., R, Vortex, GraphPad Prism, Genedata Screener, etc).

• Attention to detail with excellent organizational, experimental data recording, and time management skills

• Excellent written and verbal communication skills

• Innovative and flexible team-player with high energy and a demonstrated willingness to learn in a fast-paced environment

Preferred Skills, Experience and Education:

• Familiarity with automated liquid handling (SPT Dragonfly and/or Mosquito, Agilent Bravo, Tecan)

• Facile with instrumentation, able to trouble shoot problems and work with engineers to generate successful solutions to technical limitations.

• Rigorous, quantitative, detail-oriented experimentalist with an understanding of statistics.

The base salary range for this full-time position is $115,000 to $138,000 for candidates based at our headquarters in Redwood City, CA. The range displayed on each job posting is intended to be the minimum and maximum salary for the position in Redwood City and will be adjusted for the local market a candidate is based. Our salary ranges are determined by role, level, and location. Individual pay is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.

Please note that base salary is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.

Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact privacy@revmed.com.