- Job Type: Full-Time
- Function: Life Sciences R&D/Engineering
- Industry: Biotechnology
- Post Date: 09/01/2024
- Website: www.kimiatx.com
- Company Address: 740 Heinz Ave, Berkeley, California 94710, US
About Kimia
KimiaTherapeutics is a drug discovery business that uses high throughput precision chemistry in conjunction with genome editing and machine learning to uncover druggable sites at crucial nodes of intervention in human disease.Job Description
Are you excited about getting in on the ground floor of a startup company poised to revolutionize small molecule drug discovery? At Kimia Therapeutics we are building a next generation drug discovery engine by combining high-throughput chemistry and screening with state-of-the-art computational approaches to accelerate the discovery of novel drugs. At Kimia, we look for collaborative teammates who are motivated by our mission and would like to play an impactful role in the growth and success of an emerging pharmaceutical company.
Job Summary
We are seeking an experienced structural biologist to support our drug discovery programs at Kimia. The key aspect of your role will be to obtain high-resolution X-ray crystal structures of protein-small molecule complexes to inform structure-based drug design efforts. Another part of your role will be to design, express, and purify proteins or protein-ligand complexes to enable structural and biochemical studies. This is an exciting opportunity to join an innovative startup company and contribute to the discovery of novel therapies for patients. The successful candidate will play an essential role in supporting Kimia’s structural biology and protein science functions.
Responsibilities
- Obtain high-resolution X-ray crystal structures of protein-small molecule complexes (from screening crystallization conditions to data collection, processing, and model refinement)
- Be responsible for the production (from design to purification) and analytical characterization of recombinant proteins from bacterial and insect cells
- Independently perform complex experiments, manage and analyze experimental data, interpret results, and present data to senior leadership
- Collaborate closely with Medicinal Chemistry and Computational Biology to drive compound progression
- Contribute to long-term activity planning by exploring and evaluating new technologies related to structural biology and protein sciences
Qualifications
- Master’s or Ph.D. with an emphasis in Structural Biology ideally including experience in a biotechnology or pharmaceutical industry setting
- Expertise in all aspects of macromolecular structure determination of a variety of protein and protein-ligand complexes using X-ray crystallography
- Proficiency in large-scale expression and purification of challenging recombinant proteins is required, multi-protein complexes and membrane protein experience a plus
- Experience in characterizing protein reagent quality and function through analytical (DLS, HPLC, IEF, MS), biochemical (enzymatic assays, TR-FRET) and biophysical assays (SPR, BLI, ITC) a plus
- Documented ability to contribute and communicate impactful scientific findings
- Strong verbal and written communication skills and the ability to work collaboratively within a multidisciplinary team
$115,500 - $153,000 a year
The anticipated salary range for this position is $128,000 to $153,000 for Associate Scientist and $115,500 to $148,500 for Scientist. The final salary will be dependent on several factors that may include but are not limited to the type and length of experience within the job, type and length of experience within the industry, education, etc.
On top of base salary, we offer comprehensive benefits, bonus, and equity. If this range doesn't match your expectations, please still apply because we may have another opportunity for you.
We offer a vibrant startup environment where every member of the Kimia team plays an important role in shaping our science and our culture. Kimia offers competitive pay, participation in our stock option plan, and comprehensive benefits. At Kimia we believe that a diverse, open and inclusive environment is key to our success. We are proud to be equal opportunity employer and will consider all applicants for employment.
Full vaccination against COVID-19 is a condition of employment at Kimia. If you are unable to receive a COVID-19 vaccine due to a disability, or serious medical condition, or because it would violate your sincerely held religious belief, you will have an opportunity to request a reasonable accommodation.
Note to external recruiters: Please do not submit any agency resumes. Kimia will not be responsible for any fees related to resumes that are unsolicited.