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Scientist I/Scientist II/Sr Scientist, Bioanalytical Chemistry

Hexagon Bio

Menlo Park, CA, US
  • Job Type: Full-Time
  • Function: Life Sciences R&D/Engineering
  • Industry: Biotechnology
  • Post Date: 07/07/2024
  • Website: www.hexagonbio.com
  • Company Address: 1490 OBrien Dr, Menlo Park, CA, 94025

About Hexagon Bio

Hexagon Bio is a data-driven biopharma company developing targeted small molecule therapeutics. Our proprietary platform combines data science, genomics, synthetic biology, chemistry and automation to discover potent, evolutionarily-refined small molecules and their cognate targets directly from DNA sequences. We are mining fungal genomes for inspiration for the next generation of targeted therapies for diseases with unmet needs.

Job Description

About Hexagon Bio

Hexagon Bio leverages a genomics-based platform and understanding of natural product evolution to develop next-generation medicines for human disease. Hexagon Bio's algorithms identify gene clusters that encode the machinery needed to produce specialized metabolites that can be harnessed against human disease targets. Our unique platform allows us to produce new chemical leads based on these findings. We use data science, genomics, synthetic biology and automation to discover potent, evolutionarily refined small molecules and their cognate targets from fungal genomes, and apply medicinal chemistry when needed to optimize these molecules into truly transformative medicines.

We are expanding our analytical chemistry team and have an opening for a Scientist I/II/Sr Scientist level. As a bioanalytical chemist at Hexagon Bio, you will work closely with medicinal chemistry and biology teams to drive discovery projects towards the clinic.

Responsibilities

  • Antibody-drug conjugate bioanalysis in matrices including media, plasma, cell line, and tissue by techniques including immunoaffinity capture, ELISA, enzymatic linker cleavage, and LC-MS/MS
  • Antibody-drug conjugate characterization by techniques including SEC, HIC, and RP-LC-MS/MS
  • Work with CROs to implement and monitor bioanalytical activities
  • Manage timelines and resources to ensure accurate execution of bioanalytical activities
  • Stay current with emerging technologies and scientific advancements in ADCs
  • Archive results in proprietary LIMS
  • Present project updates to cross-functional partners and key stakeholders
  • Comply with company health and safety policies and general laboratory practices

 Requirements

  • Ph.D. degree in analytical or biochemistry, or BS/MS degree in chemistry, biochemistry, or related field with equivalent industry experience
  • Previous experience with antibody-drug conjugates is preferred
  • Strong background in ligand binding assays with emphasis on PK analysis
  • Knowledge and hands-on experience with technologies relevant to ligand binding assays and PK analysis
  • Excellent analytical and problem solving skills with the ability to troubleshoot experiments and propose innovative solutions
  • Effective communication and collaboration skills with the ability to work independently as part of a multidisciplinary research team
  • Ability to work in a fast-paced environment
  • Ability to work in Menlo Park, CA laboratories

 What We Offer:

  • A flexible and dynamic work environment, where you pave your own path; Hexagon cultivates the unique strengths of employees at all levels and provides mobility across departments.
  • Quarterly “All Hands Meetings” provide an opportunity to share company and team updates. These meetings are rooted in our value of transparency and designed to foster a culture of collaboration, curiosity, and open communication.
  • Discretionary paid time-off policy & paid holidays
  • Competitive compensation and a robust benefits package: a comprehensive suite of medical, dental, and vision insurance plans through TriNet, which offers additional voluntary benefits (pet insurance, accident insurance, home & auto insurance, and more).
  • Equity and a 401(k) plan.
  • Rapid career advancement for driven performers.
  • Access to scientific conferences all over the country, throughout the year.
  • A range of amenities, courtesy of the Menlo Park Labs business park including shuttle, gym, rock-climbing wall, pool, sports courts, cafe, bike lockers, and free EV charging stations.
  • Opportunities to engage with the Hexagon community through team-building events like our monthly Hexagon Happy Hour and holiday parties.

The salary range is dependent on the level of Scientist that is hired (Scientist I/Scientist II/Sr Scientist).  The salary range for this full-time position is $120,000 to $190,000 + bonus + equity + benefits. Our salary ranges are determined by role, level, and location. The range displayed on each job posting reflects the minimum and maximum target for new hire salaries for the position across California locations. Within the range, individual pay is determined by work location and additional factors, including job-related skills, experience, and relevant education or training.

Hexagon Bio is an equal opportunity employer and committed to a diverse workplace. All applicants will be considered equally without regard to race, color, ethnicity, veteran status, religion, national origin, marital status, political affiliation, age, sex, sexual orientation, disability status, membership in an organization or any other non-merit factors.

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