- Job Type: Full-Time
- Function: Clinical Research
- Industry: Biotechnology
- Post Date: 05/22/2023
- Website: www.revmed.com
- Company Address: 700 Saginaw Drive, Redwood City, CA, 94063
About Revolution MedicinesREVOLUTION Medicines discovers and develops new drugs that harness the therapeutic potential of frontier oncology targets on behalf of cancer patients. Our innovative product engine draws inspiration from nature and evolution, which offer insights into cancer targets, disease mechanisms and therapeutic approaches.
Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding scientists in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.
As a Clinical PK Manager in Clinical Pharmacology, you will:
Liaise with Clinical Pharmacology Project Leads to design and review the pharmacokinetics components of a clinical protocol, lab manual and other study associated documents.
Manage and provide technical oversight to bioanalytical CROs on regulated bioanalysis.
Facilitate clinical PK sample reconciliation and manage sample analysis timeline.
Review method validation protocols, PK sample analysis plans and study reports.
Review pharmacokinetic concentration data, conduct non-compartmental PK analysis and summarize data to drive critical study decisions.
Manage collaboration with clinical pharmacology CROs/consultants to support PK analysis for clinical study reports and relevant sections of regulatory filing documents.
Required Experience, Skills, and Education:
- MS in Analytical Chemistry, Pharmacokinetics, drug metabolism or a related scientific discipline with 5 years of relevant industry experience, or BS with over 8 years of relevant industry experience.
In-depth knowledge and hands-on experience with LC/MS/MS and quantitative analysis of small molecules in complex biological matrices.
Good understanding of regulatory guidelines for regulated bioanalysis and ADME related studies; Prior GLP experience is preferred.
Excellent interpersonal, oral, and written communication skills .
Thrives in a collaborative team setting and is driven by a desire to be innovative in a high energy, small company environment.
Revolution Medicines currently requires that all personnel and visitors to its offices be fully vaccinated against COVID-19. This role will require that the employee meet with company employees and work from the company’s offices. Given that these essential functions of the role must be performed on-site, this position requires full COVID-19 vaccination, subject to applicable law.
The expected salary range for this role is $120,000 to $158,000. An individual’s position within the range may be influenced by multiple factors, including skills and experience in role, overall performance, individual impact and contributions, tenure, and market dynamics. Base salary is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.
Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition and veteran status.