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Research Associate II, In-Vivo Pharmacology (CONTRACT)

ORIC Pharmaceuticals

South San Francisco, CA, US
  • Job Type: Full-Time
  • Function: Research Sci/Assoc/Mgr
  • Industry: Biotechnology
  • Post Date: 05/22/2023
  • Website:
  • Company Address: 240 E. Grand Ave 2nd Floor, South San Francisco, CA, 94080
  • Salary Range: $50,000 - $150,000

About ORIC Pharmaceuticals

ORIC Pharmaceuticals is a clinical stage biopharmaceutical company dedicated to improving patients’ lives by Overcoming Resistance In Cancer. ORIC’s lead product candidate, ORIC-101, is a potent and selective small molecule antagonist of the glucocorticoid receptor, which has been linked to resistance to multiple classes of cancer therapeutics across a variety of solid tumors.

Job Description

ORIC is a research-driven company dedicated to discovering and developing novel therapies that can Overcome Resistance In Cancer. Our collaborative, empowering culture gives scientists the authority, responsibility, and support to do cutting-edge work on therapies for treatment-resistant cancers. Our culture and values support our mission, provide a shared understanding of how we work together as a company and provide a clear sense of what is most important for us as an organization.

We are looking for a motivated and experienced researcher to join our In Vivo Pharmacology group.  The individual will execute in vivo efficacy and PK/PD studies in support of ORIC’s drug development programs.  Reports to the In Vivo Pharmacology group leader and collaborates extensively with DMPK and Biology teams.

 Tasks and Responsibilities:

Other duties may be assigned.

  • Demonstrates technical in vitro skills (proficiency performing in vitro cell culture, scale-up, banking and maintenance of frozen stocks)
  • Demonstrates technical in vivo skills (proficiency in handling rodents, administering therapeutics via various routes, tumor implantation and measurement, blood collection, animal necropsy)
  • Executes in vivo studies using skills focused on identifying candidate molecules and translational research within the area of oncology with guidance
  • Prepares formulation and dosing solutions
  • Collects, records and analyzes data in electronic notebook format using programs such as Microsoft Office Applications, Prism and Benchling
  • Perform all duties in keeping with the Company's core values, policies and all applicable regulations.


  • A B.Sc. in Biology, Pharmacology or related discipline with 1+ years life sciences experience with a strong focus on in vivo pharmacology in an industry setting
  • Experience in utilizing preclinical cancer models (xenograft, syngeneic and PDX) and applied technologies enabling in vivo analyses
  • Hands-on experience in relevant ex vivo experimental and molecular biology techniques such as cell culture, ELISA, qPCR, western blot, immunohistochemistry, flow cytometry and cell immunophenotyping is a plus
  • Familiarity with the regulatory requirements to remain compliant with IACUC and AALAC regulations
  • Ability to maintain proper scientific documentation associated with pharmacology studies in electronic lab notebooks, write technical reports and present summaries of research results
  • Strong communication skills and ability to work effectively in a multidisciplinary team environment
  • Highly collaborative, self-driven and detail-oriented individual
  • Other duties may be assigned.

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