Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding scientists in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

The DMPK Scientist will be part of the Nonclinical Development and Clinical Pharmacology (NDCP) Organization and play an important role in PK modeling and translational PKPD analysis for small molecule programs.

• Manage internal and external collaborations to develop and refine physiologically based PK (PBPK), quantitative systems pharmacology (QSP), and pharmacokinetic-target engagement (PK-TE) models.

• Build up infrastructure and data flow to expand and support in-house modeling and simulation capabilities.

• Develop new PBPK, QSP, PK-TE, and PKPD models to support both discovery and development phase projects.

• Ensure a high level of quality and rigor in current and future model building.

• Collaborate with cross-functional departments to support additional computational modeling efforts.

Required Experience, Skills, and Education: 

• A Ph.D. with quantitative science background (Pharmaceutical Sciences, Mathematics, Computational Biology, etc). 1-2 years of industry experience is desirable.

• Proficient in the development, calibration, and validation of ordinary differential equation (ODE) and non-linear mixed effect (NLME) models.

• Hands-on experience with modeling software is a plus (Simbiology, Phoenix WinNonlin, NONMEM, etc.).

• Able to effectively communicate modeling assumptions, limitations, and simulation results to non-specialist and specialist audiences.

• A critical thinker and team player who can effectively work with cross-functional team members.

Revolution Medicines currently requires that all personnel and visitors to its offices be fully vaccinated against COVID-19. This role will require that the employee meet with company employees and work from the company’s offices. Given that these essential functions of the role must be performed on-site, this position requires full COVID-19 vaccination, subject to applicable law.

The expected salary range for this role is $120,000 to $158,000. An individual’s position within the range may be influenced by multiple factors, including skills and experience in role, overall performance, individual impact and contributions, tenure, and market dynamics. Base salary is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition and veteran status.

Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact privacy@revmed.com.