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Senior Manager, Pharmacometrician (PK Data Scientist)

Revolution Medicines

Redwood City, CA, US
  • Job Type: Full-Time
  • Function: Data Science
  • Industry: Biotechnology
  • Post Date: 02/06/2023
  • Website: www.revmed.com
  • Company Address: 700 Saginaw Drive, Redwood City, CA, 94063
  • Salary Range: $150,000 - $190,000

About Revolution Medicines

REVOLUTION Medicines discovers and develops new drugs that harness the therapeutic potential of frontier oncology targets on behalf of cancer patients. Our innovative product engine draws inspiration from nature and evolution, which offer insights into cancer targets, disease mechanisms and therapeutic approaches.

Job Description

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit high-value frontier targets in RAS-addicted cancers.  The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding scientists in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

We are seeking a passionate and energetic individual with strong data analysis background to be part of the Nonclinical Development and Clinical Pharmacology (NDCP) Organization. As a key PK Data Scientist to support the pharmacometrics functions in the department, you will;

  • Build the internal infrastructure for PKPD data preprocessing and visualization.

  • Develop and manage automatic workflows (i.e. data uptake, QC, data integration and reformatting) for clinical PKPD and endpoint data.

  • Apply statistical and computational methods to analyze complex PKPD data.

Required Experience, Skills, and Education:

  • A Ph.D. or M.S. with a quantitative science background (mathematics, statistics, engineering, pharmaceutical sciences, computational biology, etc.).

  • Must be proficient in R programming and development of R-Studio / Shiny apps.

  • Must have working knowledge in time series analysis in the graduate coursework and/or postgraduate job functions.

  • Must be familiar with the concepts of repeated measures and mixed models.  

  • Able to take dynamically assigned pharmacometrics tasks and deliver the results in a timely manner.

  • Excellent verbal and written communication skills, and ability to clearly convey complex concepts and findings to both non-specialist and specialist audiences.

  • A critical thinker and passionate team player and quick learner with high energy who thrives in a dynamic and fast-paced environment.

  • Demonstrated experience and track record in clinical-stage drug development is a big plus but not required.

  • Hands-on experience using commerical and/or open source ODE / PKPD modeling software is desired.

Revolution Medicines currently requires that all personnel and visitors to its offices be fully vaccinated against COVID-19. This role will require that the employee meet with company employees and work from the company’s offices. Given that these essential functions of the role must be performed on-site, this position requires full COVID-19 vaccination, subject to applicable law.

The expected salary range for this role is $150,000 to $190,000. An individual’s position within the range may be influenced by multiple factors, including skills and experience in role, overall performance, individual impact and contributions, tenure, and market dynamics. Base salary is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition and veteran status.

Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact privacy@revmed.com.

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