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Associate Director, Toxicology, Non-Clinical Development & Clinical Pharmacology

Revolution Medicines

Redwood City, CA, US
  • Job Type: Full-Time
  • Function: Research Sci/Assoc/Mgr
  • Industry: Biotechnology
  • Post Date: 05/22/2023
  • Website:
  • Company Address: 700 Saginaw Drive, Redwood City, CA, 94063
  • Salary Range: $175,000 - $210,000

About Revolution Medicines

REVOLUTION Medicines discovers and develops new drugs that harness the therapeutic potential of frontier oncology targets on behalf of cancer patients. Our innovative product engine draws inspiration from nature and evolution, which offer insights into cancer targets, disease mechanisms and therapeutic approaches.

Job Description

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit high-value frontier targets in RAS-addicted cancers.  The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding scientists in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

In anticipation of the Company’s growth plans, we are seeking an experienced Toxicologist to lead safety strategies for small molecule discovery programs and work in close collaboration with colleagues in Research and Development to enable the advancement of portfolio programs. The ideal candidate will deliver a balanced assessment of the risk/ benefit profile associated with a drug candidate by integrating pharmacology/ toxicology studies and engaging with stakeholders to align on a tractable clinical development plan. Further, the ideal candidate will:

  • Function as a project toxicologist on drug discovery and development project teams and be a strong advocate for patient safety.

  • Design and oversee nonclinical toxicology programs and strategies to advance pipeline of small molecule cancer therapeutics from research phase through clinical development programs.

  • Effectively implement and oversee studies outsourced to CROs, in collaboration with study operations, pharmacology, DMPK and clinical pharmacology functions.

  • Analyze, interpret, and summarize nonclinical safety data, and present and contextualize meaningful findings and recommendations to internal project teams and leadership.

  • Ensure timely and accurate nonclinical study deliverables of projects to enable compound progression and decision-making, including drafting and review of nonclinical sections of regulatory documents.

  • Develop and implement target de-risking, screening, issue mitigation, and resolution strategies for toxicities observed in vivo.

 Required Experience, Skills, and Education:

  • Ph.D. degree in toxicology, pharmacology, or related discipline with 5+ years of leadership experience in toxicology project development; DABT certification is desirable.

  • Experience preparing nonclinical safety sections supporting IND/NDA submissions using CTD format.

  • Interactions with FDA and other regulatory agencies.

  • A thorough understanding of GLP regulations as well as US and ex-US regulatory guidance documents.

  • Experience with small molecules; prior experience with targeted oncology therapeutics is highly desirable.

  • Strong scientific background and scientific aptitude with excellent critical thinking skills.

  • Ability to work effectively and collaboratively on cross-functional project teams; demonstrated ability to multi-task, prioritize options, anticipate challenges, and execute goals as a member of an interdisciplinary team is extremely important.

  • Excellent verbal, presentation, and written communication skills.

  • Thrives in a collaborative team setting and is driven by a desire to be innovative in a high-energy, small company environment.

Revolution Medicines currently requires that all personnel and visitors to its offices be fully vaccinated against COVID-19. This role will require that the employee meet with company employees and work from the company’s offices. Given that these essential functions of the role must be performed on-site, this position requires full COVID-19 vaccination, subject to applicable law.

The expected salary range for this role is $175,000 to $210,000. An individual’s position within the range may be influenced by multiple factors, including skills and experience in role, overall performance, individual impact and contributions, tenure, and market dynamics. Base salary is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition and veteran status.

Come join the REVOLUTION!

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