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Senior Principal/Principal Scientist, DMPK

ORIC Pharmaceuticals

South San Francisco, CA, US
  • Job Type: Full-Time
  • Function: Life Sciences R&D/Engineering
  • Industry: Biotechnology
  • Post Date: 11/22/2022
  • Website:
  • Company Address: 240 E. Grand Ave 2nd Floor, South San Francisco, CA, 94080

About ORIC Pharmaceuticals

ORIC Pharmaceuticals is a clinical stage biopharmaceutical company dedicated to improving patients’ lives by Overcoming Resistance In Cancer. ORIC’s lead product candidate, ORIC-101, is a potent and selective small molecule antagonist of the glucocorticoid receptor, which has been linked to resistance to multiple classes of cancer therapeutics across a variety of solid tumors.

Job Description

We are seeking a highly motivated Principal Scientist/Senior Principal Scientist with in-depth experience in DMPK for small molecule drug discovery and development. The successful candidate will play a key role in our project teams, who are dedicated to developing therapeutics to overcome resistance in cancer. Reporting to the Head of Preclinical Development, the person will focus on providing project team support and scientific guidance as well as oversight of DMPK activities. The successful candidate will thrive in partnering with discovery research and development teams to identify clinical candidates and support regulatory filings. Expectations include independently planning, executing and analyzing in-house or outsourced studies, interpreting and presenting results, as well as managing and coaching junior scientists

Duties and Responsibilities:

  • Utilize experimental and in silico data along with scientific acumen for in vitro ADME and in vivo PK profiling. Areas of proficiency include metabolic biotransformation assays, transporter/enzyme substrate/inhibitor characterization, in vivo PK in various animal models, NCA, and contribution to SAR analysis.
  • Contribute to/independently establish ADME strategies to identify key attributes and liabilities of compounds, remedial strategies and application of key ADME concepts to help teams select successful drug candidates.
  • Contribute to project team meetings as DMPK subject matter expert.
  • Actively collaborate with key scientists across departments e.g. Medicinal Chemistry, in vitro and in vivo Biology, Toxicology, CMC.
  • Support the DMPK team with hands on experience in operating, maintaining and troubleshooting LC-MSs.
  • Support and manage junior scientists on bench related activities (including LC/MS method development and quantitative sample bio-analysis), data analysis and scientific strategies.
  • Participate in the selection, qualification, and management of CROs.
  • Co-author high quality Regulatory documents in support of IND, CTA, NDA, etc. Assist in the preparation of DMPK components of nonclinical study protocol designs, nonclinical study reports, IND sections, and IBs.
  •     Participate in the preparation of abstracts and manuscripts for publication.

Perform all duties in keeping with the Company’s core values, policies and all applicable regulations.

Education and Experience:

  • in Drug Metabolism, Chemistry, Pharmacokinetics, Pharmaceutical Sciences or other relevant field with 7+ years of experience, or with M.S. degree with 15+ years of experience, or with B.S. with 20+ years of experience in the biopharmaceutical industry
  • Scientific and technical knowledge in ADME principles and profiling techniques is a must.
  • Expertise and extensive experience in the design, conduct, and data interpretation from common in vitro/in vivo studies as well as with LC/MS-based analysis are essential.
  • Experience and knowledge with regulatory requirements are highly desired, as are up-to-date knowledge in principles of drug development.
  • Track record of managing collaborations with CROs for outsourced activities is highly desired.
  • Excellent interpersonal skills and ability to represent DMPK in cross functional project teams.
  • Excellent oral and written communication skills.

A strong fit with ORIC’s culture and core values of commitment to excellence, patient-centered and collaboration

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