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Senior Scientist I/Associate Director, Structural Biology

Revolution Medicines

Redwood City, CA, US
  • Job Type: Full-Time
  • Function: Life Sciences R&D/Engineering
  • Industry: Biotechnology
  • Post Date: 11/22/2022
  • Website: www.revmed.com
  • Company Address: 700 Saginaw Drive, Redwood City, CA, 94063

About Revolution Medicines

REVOLUTION Medicines discovers and develops new drugs that harness the therapeutic potential of frontier oncology targets on behalf of cancer patients. Our innovative product engine draws inspiration from nature and evolution, which offer insights into cancer targets, disease mechanisms and therapeutic approaches.

Job Description

REVOLUTION Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit high-value frontier targets in RAS-addicted cancers.  The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding scientists in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

As a key contributor to our Structural Biology team, you will:

  • Partner and integrate with multidisciplinary, highly collaborative discovery teams to design, optimize, and accelerate the development of novel drug candidates using advanced SB techniques.

  • Mentor early career scientists in designing, executing, and interpreting experiments to drive progress in multiple programs.

  • Work closely with internal and external teams of protein scientists, biophysicists, and X-Ray crystallography scientists as part of an integrated structural biology effort. Experience with insect and/or mammalian cell expression/purification highly desirable.

  • Maximize the impact of structural information and associated data in drug discovery programs.

  • Provide x-ray crystallographic and protein structure-function support, including structure-based drug design, to on-going drug discovery projects and new target discovery initiatives.

  • Perform protein crystallography, including initial screening, crystal quality optimization, data collection, and structure determination.

  • Provide innovative ideas and models to challenge and shape project thinking; serve as a lead Structural Biologist on drug discovery projects.

Required Experience, Skills, and Education:

  • Ph.D. with 5+ years of relevant experience in the biotechnology/pharmaceutical industry.

  • A track record of impact in drug design efforts as evidenced by publications and patents.

  • Expertise in analysis and interpretation of protein ligand complexes.

  • Expertise with standard software packages (Phenix, CCP4, Coot, Pymol, 3Decision, CryoSPARC).

  • A desire to participate in a highly creative and interdisciplinary environment.

  • Experienced people leadership of early career scientist including evidence of successful coaching, mentorship and development of individuals in order to build long-term organizational capability.

  • Deep understanding and extensive experience with X-ray crystallography is required. Experience with cryoEM is a plus as well as a familiarity with other structural methods such as HDX-MS and SAXS.

  • Thrives in a collaborative team setting and is driven by a desire to be innovative in a high energy start-up environment.

  • Excellent written and verbal communication skills and ability to present to a wide variety of audiences.

Revolution Medicines currently requires that all personnel and visitors to its offices be fully vaccinated against COVID-19. This role will require that the employee meet with company employees and work from the company’s offices. Given that these essential functions of the role must be performed on-site, this position requires full COVID-19 vaccination, subject to applicable law.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition and veteran status.

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