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Senior Scientist, Cancer Targets & Technology

Revolution Medicines

Redwood City, CA, US
  • Job Type: Full-Time
  • Function: Life Sciences QA/QC
  • Industry: Biotechnology
  • Post Date: 11/22/2022
  • Website: www.revmed.com
  • Company Address: 700 Saginaw Drive, Redwood City, CA, 94063

About Revolution Medicines

REVOLUTION Medicines discovers and develops new drugs that harness the therapeutic potential of frontier oncology targets on behalf of cancer patients. Our innovative product engine draws inspiration from nature and evolution, which offer insights into cancer targets, disease mechanisms and therapeutic approaches.

Job Description

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit high-value frontier targets in RAS-addicted cancers.  The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding scientists in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

  • Develop robust cell-based pharmacogenomic screens and other methods to identify and validate potential cancer targets to expand the pipeline.

  • Design, conduct, and manage experiments in-house or at contract research organizations (CROs) to validate targets using pharmacologic or genetic approaches in relevant in vitro cellular models.

  • Identify, champion, and develop technologies to increase pharmacogenomicscreening and target validation capabilities.

  • Analyze and interpret experimental data and present results at internal meetings and scientific conferences.

  • Collaborate with biologists, pharmacologists, and data scientists to generate novel insights into key drivers of RAS-addicted cancers and participate in strategic decisions regarding the initiation of new therapeutic programs.

Required Experience, Skills, and Education:

  • Ph.D. in Molecular/Cell Biology, Cancer Biology, or related field with 5+ years of postdoctoral and/or relevant biopharmaceutical industry research experience; industry experience is preferred.

  • Outstanding, rigorous, and productive experimentalist with strong critical thinking skills and deep knowledge of cellular signaling networks.

  • Knowledge of oncogenic signaling pathways, particularly the RAS-MAPK pathway, is preferred.

  • Practical experience with mammalian cell culture and engineering, particularly with the development of cell-based functional assays.

  • Expertise with functional genomic screening approaches (e.g. CRISPR Ko, CRISPRi, and CRISPRa) and relevant assay readout technologies (e.g. alphaLISA/MSD, TR-FRET/BRET, luminescence, high-content microscopy, flow cytometry, NGS based technologies, etc.).

  • Ability to analyze large datasets and familiarity with relevant data processing and visualization tools (e.g. Genedata Screener, KNIME, R, or Spotfire).

  • Excellent written and verbal communication skills, strong interpersonal skills, and a high degree of self-awareness with a flexible growth mindset.

  • Demonstrated ability to multi-task, prioritize options, anticipate challenges, collaborate, and execute on goals as a member of an interdisciplinary team in a high-energy, fast-moving environment.

Revolution Medicines currently requires that all personnel and visitors to its offices be fully vaccinated against COVID-19. This role will require that the employee meet with company employees and work from the company’s offices.  Given that these essential functions of the role must be performed on-site, this position requires full COVID-19 vaccination, subject to applicable law.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.

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