Career | <?phpecho $jobTitle;?> | <?phpecho $companyName;?>

Senior Research Associate I / II, Upstream Process Development

Synthekine

Menlo Park, CA, US
  • Job Type: Full-Time
  • Function: Research Sci/Assoc/Mgr
  • Industry: Biotechnology
  • Post Date: 09/20/2022
  • Website: synthekine.com
  • Company Address: 1505 Obrien Drive, Suite A/D, Menlo Park, California 94025, US

About Synthekine

Synthekine is an engineered cytokine therapeutics company developing disease-optimized treatments. The company uses immunological insights to guide targeted protein engineering to generate transformative medicines for cancer and autoimmune disorders.

Job Description

Synthekine is a Menlo Park, CA based biotechnology company focused on discovering and developing best in class cytokine therapeutics to treat cancer and autoimmunity. We use our unique insights on how cytokines bind to their receptors and tune these systems though protein engineering to generate therapeutics that have transformative potential. Synthekine was formed in 2019 and has raised $190M from leading biotech investors. We are advancing a deep pipeline of therapeutics against some of the most important cytokine targets. Come join us and help us give patients and physicians better options to treat disease and advance cytokine science along the way.

Position Summary:

Our Process Development team is looking for a talented & driven upstream senior research associate to play a key role in the development and execution of upstream processes for Synthekine’s various drug candidates. The successful candidate will show an aptitude and affinity for working with upstream scientists towards developing robust fermentation and/or cell culture processes for transfer to manufacturing facilities.

Key responsibilities include supporting production of recombinant protein and/or antibody expression in mammalian host systems in bench top scale and bioreactors. You will support cell culture process scale-up to support early and late-stage projects. This position reports to the Director, Process Development.

Key Responsibilities:

  • Maintain mammalian and/or fermentation cell cultures/fermentations in shake flask experiments and/or bioreactor experiments
  • Working with upstream development scientists to effectively execute experiments with a goal to increase product expression, process characterization, and process robustness
  • Media formulation, bioreactor building and breakdowns, sampling and sample analysis
  • Monitoring and troubleshooting of shake flask and/or bioreactor experiments
  • Working with upstream development scientists on any tasks that may be assigned relating to upstream process development
  • Robust documentation in electronic laboratory notebook system
  • Review of reports related to upstream process development
  • Data review and presentation may be required
  • Develop an experimental plan and be able to execute cell culture and/or fermentation studies in laboratory
  • Perform routine laboratory operations such as seed culture expansion in shake flasks and bioreactors, production cultures in shake flasks, wave bag and single use bioreactors, product harvest, routine in-process analytical testing, etc.
  • Support process optimization and process characterization work to develop scalable and manufacturing friendly processes
  • Some nights and weekends may be required for sampling, inoculation, troubleshooting

Requirements:

  • SRA I Level: BS in Biology, Biochemistry or Chemical/Biochemical engineering or in a related life-sciences field with of 2-5 years of experience in cell culture/fermentation process development and/or manufacturing sciences supporting cell culture operation in the biopharmaceutical/biotechnology industry.
  • SRA II Level: BS in Biology, Biochemistry or Chemical/Biochemical engineering or in a related life-sciences field with 6+years of experience in cell culture/fermentation process development and/or manufacturing sciences supporting cell culture operation in the biopharmaceutical/biotechnology industry.
  • 3yearsof hands-on experience in process scale-up or operation of large-scale bioreactors and cell culture equipment desired
  • Excellent aseptic technique a must
  • Ability to think critically, analytically and to have strong troubleshooting and problem-solving skills based on deductive reasoning.
  • Self-motivated with the ability to work independently and collaboratively in cross functional teams
  • Excellent interpersonal, verbal and written communication skills
  • Proven ability to manage ambiguity and thrive in startup environments to build and establish new facilities, teams, and processes
  • Ability to work with a sense of urgency in a fast-paced environment

Synthekine requires all new hires to be fully vaccinated prior to the first date of employment (subject to any legally required exemptions).

Synthekine is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.

We use cookies to customize your user experience. Click “Agree” if you agree with our Policy.