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Senior/Principal Scientist, Computational Chemistry

Carmot Therapeutics

Berkeley, CA, US
  • Job Type: Full-Time
  • Function: Life Sciences R&D/Engineering
  • Industry: Biotechnology
  • Post Date: 11/22/2022
  • Website:
  • Company Address: 740 Heinz Avenue, Berkeley, CA, 94710

About Carmot Therapeutics

Carmot Therapeutics, Inc. is a clinical-stage company dedicated to the discovery and development of innovative medicines. Carmot applies a transformative, patented drug discovery approach, Chemotype Evolution to explore novel frontiers of chemistry and biology. Using Chemotype Evolution, Carmot has developed a portfolio of drug candidates in metabolic disease and oncology.

Job Description

Carmot Therapeutics is a clinical stage biotechnology company dedicated to the discovery and development of innovative medicines for the treatment of metabolic diseases and cancer. Carmot is applying an innovative technology, Chemotype Evolution, to overcome the limitations of conventional drug discovery technologies to identify drugs for the most challenging of therapeutic targets. As a result of our strong scientific progress, we are seeking a creative, highly motivated, and experienced individual to enable computational chemistry for our discovery programs and Chemotype Evolution.

Building on our success in discovery novel drug candidates, we are seeking a talented and ambitious computational chemist with a background in structure-based drug design (SBDD) to join our multidisciplinary team. In this position, you will develop and apply novel computational strategies to support Chemotype Evolution library designs. In addition, you will play a key role in advancing novel hit compounds to leads using state of the art computational methods to inspire new compound designs and medicinal chemistry optimization. Key responsibilities include:

  • Deployment of a range of computational methods (e.g., docking, pharmacophore modeling, etc) in tandem with analysis of real-world SAR to design novel drug-like compounds
  • Collaboration with structural biology and medicinal chemistry teams to test and implement computational predictions
  • Develop and apply novel computational methods to extract information from extensive SAR data sets generated through Chemotype Evolution
  • Tracking external developments in the fields of molecular modeling, SBDD, machine learning and related areas, and applying relevant tools to active and future projects


  • Ph.D. in a computational chemistry or related discipline with 5+ years of experience in a biotech/pharma setting
  • Practical knowledge of structure-based drug design, modern computational chemistry techniques and cheminformatic tools; expertise with one or more computational suites (e.g. MOE, Maestro) is required
  • Working knowledge of medicinal (SAR), synthetic, and physical organic chemistry principles
  • Ability to influence decision-making through effective communication to non-specialists of modeling methods and outcomes
  • Ability to interact effectively in a multidisciplinary team in a fast-paced and dynamic research environment

This position is located at our Berkeley site. Carmot offers competitive compensation, comprehensive benefits, and participation in our stock option plan. Carmot Therapeutics, Inc. is committed to equal employment opportunity, regardless of age, ancestry, color, disability (mental and physical), exercising the right to family care and medical leave, gender, gender expression, gender identity, genetic information, marital status, medical condition, military or veteran status, national origin, political affiliation, race, religious creed, sex (includes pregnancy, childbirth, breastfeeding and related medical conditions), and sexual orientation.

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