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VP/SVP, Head of Neurometabolism


New York City, NY, US
  • Job Type: Full-Time
  • Function: Life Sciences R&D/Engineering
  • Industry: Biotechnology
  • Post Date: 08/01/2022
  • Website:
  • Company Address: 430 E. 29th Street, New York, NY, 10016

About Kallyope

Kallyope is a platform biotechnology company dedicated to unlocking the therapeutic potential of the gut-brain axis. The company integrates cutting-edge technologies in sequencing, computational biology, neural imaging, cellular and molecular biology, and human genetics to provide an understanding of gut-brain biology that will lead to transformational therapeutics that improve human health.

Job Description

Kallyope, a New York City-based biotechnology company, is seeking an experienced, creative, and self-motivated neuroscientist with expertise in metabolism to lead a team engaged in the discovery of novel targets, pathways and drugs that act within the gut-brain axis to treat metabolic, neurological and neuroinflammatory diseases.  Reporting to the Chief Scientific Officer, the successful applicant will guide Kallyope’s neurometabolism strategy and oversee internal and external neurometabolism drug discovery from target identification through candidate nomination.  The team employs cutting-edge techniques, including single cell sequencing, circuit-tracing, chemogenetics and behavioral phenotyping, and has access to fully equipped laboratories and an on-site vivarium. This is a unique opportunity to impact both the strategy and execution of multiple programs driven by Kallyope’s leading biology on the gut and gut-brain axis.   


  • Develop, continually refine, and execute the strategy for identifying and validating drug targets within the gut-brain axis for the treatment of metabolic disorders and neurological diseases.
  • Oversee and facilitate ongoing drug discovery programs in multiple therapeutic areas related to metabolism and neurological diseases.
  • Leverage state-of-the-art techniques to identify and validate new targets within the gut-brain axis with the potential to treat metabolic, neurological and neuroinflammatory diseases.
  • Manage, mentor and facilitate career development for employees in the discovery teams.
  • Identify and manage external academic and contract research organization (CRO) collaborations that can facilitate progression of Kallyope’s metabolism and neuroscience programs.
  • Manage and prioritize internal and external (CRO) resources to drive decisions and meet goals and timelines.
  • Interact with current and potential investors to present Kallyope’s vision and strategy in metabolism and neurological diseases areas.
  • Collaborate effectively with other functions within Kallyope such as in vivo and in vitro pharmacology, sequencing, genetics and computational biology.


  • Applicants must have a Ph.D. degree in a biological field and at least 10 years of drug discovery experience in the relevant areas in the pharmaceutical/biotechnology industry OR 7-10 years of demonstrable success as an independent academic neuroscientist.  Experience in metabolism, neurodegenerative disease and/or neuroimmunology is preferred.
  • Demonstrated success in leading and progressing drug discovery or basic research projects from conception/target identification to clinical testing.
  • Ability to creatively solve problems, prioritize resources and make crisp decisions.
  • Familiarity with cutting-edge in vitro and in vivo neuroscience and pharmacology techniques such as chemogenetics, optogenetics, circuit tracing, adeno-associated virus (AAV)-mediated expression, behavioral phenotyping, histology/immunocytochemistry and human genetics.
  • Experience managing external collaborations.
  • Track record of providing creative, inspirational leadership and management of Ph.D., M.S. and/or B.S. level personnel.
  • Demonstrated ability to work effectively in a collaborative setting.
  • Outstanding oral and written communication skills as evidenced by a solid publication and presentation record.
  • Ability to work onsite at the Kallyope laboratories at least 3 days/week.

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