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Senior Director, Project Team Leader Immuno-oncology


South San Francisco, CA, US
  • Job Type: Full-Time
  • Function: Life Sciences R&D/Engineering
  • Industry: Biotechnology
  • Post Date: 08/01/2022
  • Website:
  • Company Address: 333 Oyster Point Blvd, South San Francisco, CA, 94080

About NGM Bio

NGM Biopharmaceuticals is a privately-held drug discovery company committed to identifying transformational medicines that dramatically improve human health. Based on emerging human clinical and genetic observations, the company has devised several innovative experimental approaches to discover new therapies for the treatment of metabolic andcardiovascular diseases.

Job Description

NGM Biopharmaceuticals, Inc., a biotechnology company focused on discovering and developing novel, life-changing medicines for people whose health and lives have been disrupted by disease, is a leader in the emerging area of immuno-oncology R&D known as myeloid checkpoint inhibition.  We have built a comprehensive myeloid reprogramming and checkpoint inhibition portfolio with three disclosed product candidates targeting four receptors – ILT2, ILT3, ILT4 and LAIR1 – engineered to reprogram myeloid cells to reverse the suppression of immune responses to tumor cells. In addition, we are developing an antagonist antibody designed to inhibit GFRAL discovered as a result of our research into metabolism and autonomic nervous system regulation of the immune system.  These product candidates are the fruits of our biology-centric drug discovery approach, which aims to seamlessly integrate interrogation of complex disease-associated biology and protein engineering expertise to unlock proprietary insights that are leveraged to generate promising product candidates and enable their rapid advancement into proof-of-concept studies. As explorers on the frontier of life-changing science, we aspire to operate one of the most productive research and development engines in the biopharmaceutical industry and our research team has a track record of producing an average of one new IND candidate per year. Today the company has seven disclosed programs, including four in Phase 2 or 2b studies, across three therapeutic areas: cancer, retinal diseases, and liver and metabolic diseases.

We are seeking an experienced professional in the principles of project team leadership with demonstrated ability to manage drug development projects in oncology and immuno-oncology from early- to late-stage development.  The Senior Director will report into the VP of Project Team Leadership and will work closely with the project management and cross-functional teams to define project strategy, develop integrated project plans, and implement plans to meet business objectives.  This position will be accountable for steering immune-oncology drug development teams through corporate goal and budget planning processes.  


  • Responsible for leading 1 or more immune oncology drug development programs
  • Partnering with key stakeholders to develop program vision, strategy, compound evaluation, project scope, project milestones, risk assessment and management strategies, as well as project investment requirements
  • Utilizing deep understanding of disease biology, patient populations, biomarker strategy, and global drug development to effectively lead Project Teams to generate integrated development plans aligned with the project vision and strategy, and to drive strategic decisions for the program(s)
  • Leading cross-functional Project Teams focused on the development of novel immune-oncology large molecules
  • Coordinating closely with all cross-functional team members to ensure efficient, effective and seamless development of our programs
  • Promoting a culture of innovation within Project Teams in order to bring forward creative development plans that maximize the potential of the drug candidates and are aligned with the Company’s overall strategic intent
  • Acting as a single point of contact/communication with executive leadership, corporate partner(s), and Board of Directors
  • Providing direction and leadership to the Program team including oversight of cross-functional activities
  • Collaborating with PM on budget and integrated timeline planning
  • Given the nature of organization, must be willing and able to perform both tactical, operational work (agendas, minutes, timelines), as well as engage and drive strategic dialogue across all stages of development and all levels of leadership

Preferred Qualifications

  • Advanced degree in a relevant discipline, preferably in the life sciences or medicine (MD/ PhD/ PharmD); MS and/or MBA will be considered
  • 10+ years of biotech/pharmaceutical industry experience
  • Demonstrated in depth knowledge of drug development, primarily in late stage preclinical research and early stage clinical development
  • Experience in Immuno-oncology is desired
  • Late stage drug development experience is a plus
  • Experience leading teams in a matrix environment
  • Demonstrated ability to motivate teams
  • Ability to cultivate excellent cross-functional collaborations
  • Decision-making and analytical skills
  • Excellent communication and influencing skills with a proven ability to work with executive management and corporate partners

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