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Senior Director, Oncology Clinical Development

NGM Bio

South San Francisco, CA, US
  • Job Type: Full-Time
  • Function: Clinical Research
  • Industry: Biotechnology
  • Post Date: 08/01/2022
  • Website: ngmbio.com
  • Company Address: 333 Oyster Point Blvd, South San Francisco, CA, 94080

About NGM Bio

NGM Biopharmaceuticals is a privately-held drug discovery company committed to identifying transformational medicines that dramatically improve human health. Based on emerging human clinical and genetic observations, the company has devised several innovative experimental approaches to discover new therapies for the treatment of metabolic andcardiovascular diseases.

Job Description

NGM Biopharmaceuticals, Inc., a biotechnology company focused on discovering and developing novel, life-changing medicines for people whose health and lives have been disrupted by disease, is a leader in the emerging area of Immuno-Oncology R&D known as myeloid checkpoint inhibition.  We have built a comprehensive myeloid reprogramming and checkpoint inhibition portfolio with three disclosed product candidates targeting four receptors – ILT2, ILT3, ILT4 and LAIR1 – engineered to reprogram myeloid cells to reverse the suppression of immune responses to tumor cells. In addition, we are developing an antagonist antibody designed to inhibit GFRAL discovered as a result of our research into metabolism and autonomic nervous system regulation of the immune system.  These product candidates are the fruits of our biology-centric drug discovery approach, which aims to seamlessly integrate interrogation of complex disease-associated biology and protein engineering expertise to unlock proprietary insights that are leveraged to generate promising product candidates and enable their rapid advancement into proof-of-concept studies. As explorers on the frontier of life-changing science, we aspire to operate one of the most productive research and development engines in the biopharmaceutical industry and our research team has a track record of producing an average of one new IND candidate per year. Today the company has seven disclosed programs, including four in Phase 2 or 2b studies, across three therapeutic areas: cancer, retinal diseases, and liver and metabolic diseases.

NGM Bio is seeking a Senior Director of Clinical Research to lead our Oncology clinical trial strategy and execution, and to help build the Oncology Clinical Development team as we grow and expand.  The ideal candidate will be a motivated and knowledgeable Physician/Scientist who will implement clinical development strategies and execution of clinical studies for one or more of NGMs assets by leveraging a thorough understanding of the Oncology and Immuno-Oncology disease landscape, unmet clinical need, competitive intelligence, and other salient factors. 

Reporting into the Vice President of Oncology Clinical Development, the Senior Director of Clinical Research will act as the medical and scientific expert on relevant programs and will collaborate closely with internal project team leads and cross-functional team members to apply emerging data and information to build, revise or update and execute the development strategy as appropriate.  We are seeking candidates excited to ramp up quickly in a fast-paced environment, and who are interested in working across multiple Oncology therapeutic areas.

Responsibilities for Role

  • Function as medical expert on one or more NGM clinical development programs
  • Provide medical and scientific expertise into clinical development and protocol writing activities
  • Serve as expert medical and scientific point of contact for regulatory and ethics committee interactions
  • Plan and participate in data analysis and creation of key study-related outputs such as clinical study reports and publications
  • Develop and maintain relationships with external stakeholders such as key opinion leaders
  • Serve as medical monitor on relevant clinical trials
  • Build, train, and mentor the Oncology Clinical Development function as we grow

Required Experience

  • MD or Equivalent
  • 5+ years of clinical experience at a pharmaceutical, CRO or biotechnology company
  • Experience in Oncology clinical trials
  • Patient care experience in neck, head, or lung a plus
  • BLA/NDA experience is a plus
  • Knowledge of data analysis and interpretation as and understanding of clinical development safety and pharmacovigilance principles

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