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Senior Research Associate / Associate Scientist, Protein Analytics and Purification


South San Francisco, CA, US
  • Job Type: Full-Time
  • Function: Research Sci/Assoc/Mgr
  • Industry: Biotechnology
  • Post Date: 08/01/2022
  • Website:
  • Company Address: 333 Oyster Point Blvd, South San Francisco, CA, 94080

About NGM Bio

NGM Biopharmaceuticals is a privately-held drug discovery company committed to identifying transformational medicines that dramatically improve human health. Based on emerging human clinical and genetic observations, the company has devised several innovative experimental approaches to discover new therapies for the treatment of metabolic andcardiovascular diseases.

Job Description

NGM Biopharmaceuticals, Inc. is focused on discovering and developing novel, life-changing medicines for people whose health and lives have been disrupted by disease.  Our biology-centric drug discovery approach aims to seamlessly integrate interrogation of complex disease-associated biology and protein engineering expertise to unlock proprietary insights that are leveraged to generate promising product candidates and enable their rapid advancement into proof-of-concept studies. As explorers on the frontier of life-changing science, we aspire to operate one of the most productive research and development engines in the biopharmaceutical industry and our research team has a track record of producing an average of one new IND candidate per year. Today the company has seven disclosed programs, including four in Phase 2 or 2b studies, across three therapeutic areas: cancer, retinal diseases, and liver and metabolic diseases.

We are currently seeking a Senior Research Associate or Associate Scientist with a passion for innovation, teamwork, and performing impactful science, with a strong background in protein biochemistry.  The successful candidate will join our Protein Purification and Analytics team.  Working effectively within a dynamic and highly interactive Biologics Group and the larger Research Group, the successful candidate will work in teams to provide cutting edge protein analytics for solving protein production challenges and verifying protein quality and developability.  The position will enable the candidate to perform a wide range of cutting-edge techniques and provide broad opportunities for professional growth.


  • Lead technical initiatives in protein analytics, purification and automation.  
  • Represent protein sciences on project teams for interesting biological drug candidates.
  • Perform mass spectrometry-based characterization, as well as a broad range of protein analytics, on protein drug candidates to assess their developability
  • Present findings internally to various stakeholders


  • Deep understanding of protein chemistry, including analyses, structure and function. 
  • Experience with mass spectrometry: intact, bottom up, post-translational modifications, reduced and non-reduced. In-gel digestion.
  • Experience with biophysical tools: DSC, DSF, ce-SDS, cIEF, mass photometry
  • Experience with analytical chromatography as applied to proteins


  • Senior Research Associate: Bachelor’s or Master’s degree with at least 5 years of relevant work experience
  • Associate Scientist: Bachelor’s or Master’s degree with at least 10 years of relevant work experience
  • Deep understanding of protein chemistry, including analyses, structure and function.
  • Strong communicative abilities, especially around scientific detail and project management.  

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